UJean-François Toussaint, inhloko yezocwaningo nentuthuko emhlabeni kaSanofi Pasteur, uxwayise ngokuthi impumelelo yemithi yokugomela i-mRNA ngokumelene ne-Covid ayiqinisekisi imiphumela efanayo yomkhuhlane.
“Kudingeka sizithobe,” esho."Imininingwane izositshela uma isebenza."
Kodwa olunye ucwaningo luphakamisa ukuthi imigomo ye-mRNA ingase ibonakale inamandla kuneyendabuko.Ezifundweni zezilwane, imigomo ye-mRNA ibonakala inikeza ukuzivikela okubanzi kumagciwane omkhuhlane.Zenza amasosha omzimba ezilwane enze amasosha omzimba ngokumelene negciwane, futhi aqeqeshe namaseli omzimba ukuthi ahlasele amangqamuzana angenwe yileli gciwane.
Kodwa mhlawumbe okubaluleke kakhulu kumkhuhlane, imigomo ye-mRNA ingenziwa ngokushesha.Isivinini sokwenziwa kwe-mRNA singavumela abenzi bomuthi wokugoma ukuthi balinde izinyanga ezimbalwa ezengeziwe ngaphambi kokukhetha ukuthi yiziphi izinhlobo zomkhuhlane abazozisebenzisa, okungase kuholele ekufaniseni okungcono.
“Uma ubungaqinisekisa amaphesenti angu-80 njalo ngonyaka, ngicabanga ukuthi lokho kungaba inzuzo enkulu yezempilo yomphakathi,” kusho uDkt. Philip Dormitzer, isikhulu esiphezulu sesayensi ye-Pfizer.
Ubuchwepheshe futhi bukwenza kube lula kubenzi bomuthi wokugomela i-mRNA ukuthi bakhe izithombe ezihlanganisiwe.Kanye nama-molecule e-mRNA ezinhlobo ezahlukene zomkhuhlane, angakwazi futhi ukwengeza ama-molecule e-mRNA ezifo ezihluke ngokuphelele zokuphefumula.
Esethulweni sikaSepthemba 9 sabatshalizimali, uModerna wabelane ngemiphumela yocwaningo olusha lapho abacwaningi banikeze khona imigomo yamagundane ehlanganisa ama-mRNA amagciwane amathathu okuphefumula: umkhuhlane wesizini, i-Covid-19 kanye ne-pathogen evamile ebizwa ngokuthi i-respiratory syncytial virus, noma i-RSV.Amagundane akhiqize amazinga aphezulu amasosha omzimba ngokumelene nawo womathathu amagciwane.
Abanye abacwaningi bebefuna umuthi wokugomela umkhuhlane wonke ongavikela abantu iminyaka eminingi ngokuvikela izinhlobo eziningi zomkhuhlane.Esikhundleni sokudutshulwa kwaminyaka yonke, abantu bangadinga kuphela i-booster njalo eminyakeni embalwa.Esimeni esihle kakhulu, ukugoma okukodwa kungase kusebenze impilo yonke.
ENyuvesi yasePennsylvania, ithimba labacwaningi eliholwa nguNorbert Pardi lenza imigomo ye-mRNA ehlanganisa amaprotheni avela kumagciwane omkhuhlane ashintshashintsha kancane nje.Ukuhlola ezilwaneni kukhomba ukuthi le mithi yokugoma ingahlala isebenza unyaka nonyaka.
Yize iModerna ingasebenzi ekugomeni umkhuhlane wendawo yonke okwamanje, "into esingathanda ngempela ukuyenza esikhathini esizayo," kusho uDkt. Jacqueline Miller, inhloko yenkampani yocwaningo lwezifo ezithathelwanayo.
Ngisho noma imigomo yomkhuhlane we-mRNA iphila ngokuvumelana nokulindelwe, cishe izodinga iminyaka embalwa ukuze ithole imvume.Izivivinyo zokugomela umkhuhlane we-mRNA ngeke zikuthole ukwesekwa okukhulu kukahulumeni okwatholwa imigomo ye-Covid-19.Futhi abalawuli ngeke babavumele ukuthi bathole ukugunyazwa kwezimo eziphuthumayo.Umkhuhlane wesizini awulona neze usongo olusha, futhi usungabalwa ngemithi yokugoma enelayisensi.
Ngakho-ke abakhiqizi kuzodingeka bathathe indlela ende ukuze bagunyazwe ngokugcwele.Uma izivivinyo zomtholampilo zakuqala ziba kahle, abenzi bemithi yokugoma kuzodingeka badlulele ezinhlolweni ezinkulu ezingahle zidinge ukwelula phakathi nezinkathi zomkhuhlane ezimbalwa.
“Kufanele kusebenze,” kusho uDkt. Bartley wase-University of Connecticut."Kodwa kusobala ukuthi yingakho senza ucwaningo - ukwenza isiqiniseko sokuthi 'kufanele' nokuthi 'wenza' kuyinto efanayo."
Isikhathi sokuthumela: Apr-21-2022